DL-Proline -2-d 1 is the deuterated-labeled DL-Proline. DL-Proline is a racemic mixture of D-Proline and L-Proline, belonging to cyclic imino acids with a five-membered ring structure. DL-Proline serves as a key structural unit in peptide synthesis. DL-Proline stabilizes β-turn conformations and affects the secondary structure of peptide segments. DL-Proline exhibits biological activities such as regulating peptide segment conformations and enhancing cyclic peptide stability. DL-Proline can be used in research on diseases related to peptide structure and function, including cancer and bacterial infections [1] [2].
In Vitro, Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
References:
[1]. Myung S, et al. DL-Proline. Acta Crystallogr C. 2005 Aug;61(Pt 8):o506-8.
[2]. De Santis P, et al. Poly(DL-proline), a synthetic polypeptide behaving as an ion channel across bilayer membranes. Biophysical chemistry. 1985 Mar;21(3-4):211-5.
In Vitro, Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
References:
[1]. Myung S, et al. DL-Proline. Acta Crystallogr C. 2005 Aug;61(Pt 8):o506-8.
[2]. De Santis P, et al. Poly(DL-proline), a synthetic polypeptide behaving as an ion channel across bilayer membranes. Biophysical chemistry. 1985 Mar;21(3-4):211-5.