DMTr-2'-O-C22-rU-3'-CE-phosphoramidite is an RNA phosphoramidite monomer. DMTr-2'-O-C22-rU-3'-CE-phosphoramidite can be used for the construction and mechanistic studies of nucleic acid molecules [1].
In Vitro, DMTr‑2'-O‑C22‑rU‑3'-CE‑phosphoramidite (compound 111) can be used to site-specifically introduce a lipophilic 2'-O-C22 modification at the uridine site in oligonucleotide synthesis, enabling the construction of double-stranded RNA (dsRNA) molecules capable of extrahepatic delivery[1].
References:
[1]. Jayaprakash K. NAIR, et al. Extra-hepatic delivery iRNA compositions and methods of use thereof. WO2023064530A1. WIPO (PCT). 2023-04-20.
In Vitro, DMTr‑2'-O‑C22‑rU‑3'-CE‑phosphoramidite (compound 111) can be used to site-specifically introduce a lipophilic 2'-O-C22 modification at the uridine site in oligonucleotide synthesis, enabling the construction of double-stranded RNA (dsRNA) molecules capable of extrahepatic delivery[1].
References:
[1]. Jayaprakash K. NAIR, et al. Extra-hepatic delivery iRNA compositions and methods of use thereof. WO2023064530A1. WIPO (PCT). 2023-04-20.