GLPBio

DPP-4

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Dipeptidyl peptidase-4 (DPP-4), originally identified in 1966 as a dipeptide naphthylamidase hydrolyzing glycyl-prolyl-beta-naphthylamide, is a membrane-associated peptidase that selectively cleaves the N-terminal penultimate proline or alanine amino acids. The most common substrates of DPP-4 include glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2), peptide YY, neuropeptide, chemokine ligand 12/stromal-derived factor-1 (CXCL12/SDF-1) and substance P. DPP-4, as a type II cell surface protein and a soluble form, has been found to be widely distributed in organs (such as the bone marrow, the lung, spleen, liver, pancreas, kidney and intestines) and body fluids (such as serum/plasma, cerebrospinal fluid, synovial fluid and semen). Besides its peptidase activity, DPP-4 has been found to be associated with immune stimulation, extracellular matrix degradation, lipid accumulation and resistance to anticancer agents.

Products Related to DPP-4(18)

  • GC12895 structure
    GC12895Saxagliptin
    CAS: 361442-04-8
    Purity: >99.50%

    Saxagliptin (BMS-477118) هو مثبط قوي ، انتقائي ، قابل للانعكاس ، منافس ونشط عن طريق الفم ثنائي الببتيداز 4 (DPP-4) (Ki = 0.6-1.3 نانومتر)

  • GC10104 structure
    GC10104Glimepiride
    CAS: 93479-97-1
    Purity: >98.00%

    Glimepiride is a second-generation sulfonylurea that stimulates pancreatic β cells to release insulin. Glimepiride is used for the treatment of type 2 diabetes mellitu as monotherapy as well as in combination with metformin or insulin.

  • GC10298 structure
    GC10298Sitagliptin phosphate monohydrate
    CAS: 654671-77-9
    Purity: >99.50%
  • GC10802 structure
    GC10802K 579
    CAS: 440100-64-1
    Purity: >98%
  • GC12235 structure
    GC12235Sitagliptin (phosphate)
    CAS: 654671-78-0
    Purity: >98.00%

    Sitagliptin (فوسفات) (MK-0431 فوسفات) هو مثبط قوي لـ DPP4 مع IC50 من 19 نانومتر في مستخلصات خلايا Caco-2.

  • GC12603 structure
    GC12603DPPI 1c hydrochloride
    CAS: 866396-34-1
    Purity: >98%

    A DPP-4 inhibitor

  • GC13949 structure
    GC13949Alogliptin Benzoate
    CAS: 850649-62-6
    Purity: >99.50%

    A DPP-4 inhibitor

  • GC14126 structure
    GC14126NVP DPP 728 dihydrochloride
    CAS: 247016-69-9
    Purity: >98%
  • GC14201 structure
    GC14201PK 44 phosphate
    CAS: 1017682-65-3
    Purity: >98%

    DPP-IV inhibitor

  • GC14786 structure
    GC14786P32/98 (hemifumarate)
    CAS: 251572-86-8
    Purity: >98%

    P32 / 98 (hemifumarate) هو مثبط قوي لـ dipeptidyl peptidase IV بقيمة Ki تبلغ 130 نانومتر.

  • GC14827 structure
    GC14827Linagliptin (BI-1356)
    CAS: 668270-12-0
    Purity: >99.50%

    A potent DPP-4 inhibitor

  • GC15130 structure
    GC15130Alogliptin (SYR-322)
    CAS: 850649-61-5
    Purity: >99.00%
  • GC15576 structure
    GC15576Teneligliptin hydrobromide
    CAS: 906093-29-6
    Purity: >99.50%

    A DPP-4 inhibitor

  • GC16613 structure
    GC16613Trelagliptin
    CAS: 865759-25-7
    Purity: >99.50%

    A DDP-4 inhibitor

  • GC16733 structure
    GC16733Vildagliptin (LAF-237)
    CAS: 274901-16-5
    Purity: >98.00%

    A DPP-4 inhibitor

  • GC17012 structure
    GC17012MK3102
    CAS: 1226781-44-7
    Purity: >99.00%

    MK3102 (MK-3102) هو مثبط قوي ، انتقائي ، نشط عن طريق الفم ويعبر الحاجز الدموي الدماغي dipeptidyl peptidase 4 (DPP-4).

  • GC17479 structure
    GC17479Trelagliptin succinate
    CAS: 1029877-94-8
    Purity: >99.50%

    A DDP-4 inhibitor

  • GC10018 structure
    GC10018Talabostat mesylate
    CAS: 150080-09-4
    Purity: >99.00%

    Talabostat mesylate (Val-boroPro mesylate ؛ PT100 mesylate) هو مثبط ثنائي الببتيداز الرابع النشط وغير الانتقائي (DPP-IV) (IC50 <4 نانومتر ؛ Ki = 0.18 نانومتر) والمثبط السريري الأول لبروتين تنشيط الأرومة الليفية (FAP) ( IC50 = 560 نانومتر) ، يثبط DPP8 / 9 (IC50 = 4/11 نانومتر ؛ Ki = 1.5 / 0.76 نانومتر) ، برولين ثنائي ببتيداز الخلية الهادئة (QPP) (IC50 = 310 نانومتر) ، DPP2 ، وبعض إنزيمات عائلة DASH الأخرى.