DSPE-PEG-DBCO, MW 2000, is a phospholipid-PEG polymer that can be used to form micelles as lipid nanoparticles (LNPs) for drug delivery [1]. DSPE-PEG-DBCO is widely used in click chemistry research to provide a bioorthogonal docking site for the synthesis of modular two-component lymph node-targeted aggregation systems [2]. DSPE-PEG-DBCO is widely used to modify LNP for coupling with T cells, thereby enabling the loading of different drug molecules onto the cells[3].
References:
[1] Oude Blenke E, Sleszynska M, Evers M J W, et al. Strategies for the activation and release of the membranolytic peptide melittin from liposomes using endosomal pH as a trigger[J]. Bioconjugate chemistry, 2017, 28(2): 574-582.
[2] Zhang L, Lai Y, Wang J, et al. Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy[J]. Advanced Science, 2026: e75770.
[3] Li X, Weller S, Clergeaud G, et al. A versatile method for conjugating lipid nanoparticles on T cells through combination of click chemistry and metabolic glycoengineering[J]. Biotechnology Journal, 2024, 19(1): 2300339.