Exendin-4 -Cys is a cysteine-modified Exendin-4. Exendin‑4 (Exenatide) is an orally active, blood-brain barrier-permeable glucagon-like peptide-1 receptor (GLP‑1 receptor) agonist [1] [2] [3].
In Vitro, Exendin-4-Cys is a cysteine-modified Exendin-4. Exendin-4 (Exenatide) is an orally active, blood-brain barrier-penetrating glucagon-like peptide-1 receptor agonist that resists dipeptidyl peptidase IV-mediated degradation. Exendin-4 can mediate multiple sugar regulatory effects, including stimulating glucose-dependent insulin secretion, inhibiting glucagon production, increasing β-cell numbers, delaying gastric emptying, reducing food intake, improving peripheral insulin sensitivity, and repairing normal pancreatic islet structure. Exendin-4 can inhibit oxidative stress, alleviate inflammatory responses, and reduce neuronal apoptosis[1][2][3].
References:
[1]. Nielsen LL, et al. Pharmacology of exenatide (synthetic exendin-4): a potential therapeutic for improved glycemic control of type 2 diabetes. Regulatory peptides. 2004 Feb 15;117(2):77-88.
[2]. Teramoto S, et al. Exendin-4, a glucagon-like peptide-1 receptor agonist, provides neuroprotection in mice transient focal cerebral ischemia. Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism. 2011 Aug;31(8):1696-705.
[3]. Martin B, et al. Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntington's disease. Diabetes. 2009 Feb;58(2):318-28.
In Vitro, Exendin-4-Cys is a cysteine-modified Exendin-4. Exendin-4 (Exenatide) is an orally active, blood-brain barrier-penetrating glucagon-like peptide-1 receptor agonist that resists dipeptidyl peptidase IV-mediated degradation. Exendin-4 can mediate multiple sugar regulatory effects, including stimulating glucose-dependent insulin secretion, inhibiting glucagon production, increasing β-cell numbers, delaying gastric emptying, reducing food intake, improving peripheral insulin sensitivity, and repairing normal pancreatic islet structure. Exendin-4 can inhibit oxidative stress, alleviate inflammatory responses, and reduce neuronal apoptosis[1][2][3].
References:
[1]. Nielsen LL, et al. Pharmacology of exenatide (synthetic exendin-4): a potential therapeutic for improved glycemic control of type 2 diabetes. Regulatory peptides. 2004 Feb 15;117(2):77-88.
[2]. Teramoto S, et al. Exendin-4, a glucagon-like peptide-1 receptor agonist, provides neuroprotection in mice transient focal cerebral ischemia. Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism. 2011 Aug;31(8):1696-705.
[3]. Martin B, et al. Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntington's disease. Diabetes. 2009 Feb;58(2):318-28.