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Gamma Secretase

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Gamma secretase (γ-secretase), a member of the intramembrane cleaving protease (i-CLiP) family, is a promiscuous di-aspartyl protease that catalyzes the regulated intramembrane proteolysis (RIP), in which substrate proteins are cleaved within their membrane-spanning domain. A functional γ-secretase is a multi-protein complex consisting of the catalytic component, presenilin (PSEN), and three protein cofactors, including nicastrin (NCT), anterior-pharynx defective-1 (APH1) and PSEN enhancer-2 (PEN2). So far, 90 substrates of γ-secretase have been identified, which are type-I transmembrane proteins, except for glutamate receptor GluR3, polycystin-1 and glucosaminyltransferase (GnT-V), and appear to function as signaling proteins regulating a wide variety of cellular events, such as Notch signaling pathway.

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    A COX-inactive enantiomer of flurbiprofen

  • GC10998 structure
    GC10998PF-03084014
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  • GC12096 structure
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  • GC12191 structure
    GC12191LY-411575
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  • GC12653 structure
    GC12653LY3039478
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  • GC12659 structure
    GC12659Begacestat
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    An inhibitor of γ-secretase

  • GC12942 structure
    GC12942DAPT (GSI-IX)
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    مثبط γ-سيكريتاز

  • GC13099 structure
    GC13099BMS 299897
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  • GC13619 structure
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  • GC13673 structure
    GC13673BMS-708163 (Avagacestat)
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    A potent inhibitor of γ-secretase

  • GC15059 structure
    GC15059Sulindac sulfide
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    سولينداك كبريتيد هو مثبط γ- سيريزاز غير تنافسي ، مع IC 50 من 20.2 ميكرومتر لنشاط γ42- سيريزاز

  • GC15364 structure
    GC15364L-685,458
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  • GC15645 structure
    GC15645Compound W
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    A Notch1 signaling modulator

  • GC15896 structure
    GC15896Z-Ile-Leu-aldehyde
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    Purity: >98.00%

    Z-Ile-Leu-aldehyde (Z-IL-CHO) هو مثبط ألدهيد ببتيد قوي وتنافسي لـ γ-secretase والشق

  • GC15899 structure
    GC15899MK-0752
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    A potent inhibitor of γ-secretase

  • GC16197 structure
    GC16197RO4929097
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  • GC16431 structure
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    A potent inhibitor of γ-secretase

  • GC17671 structure
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    Purity: >98.00%

    مثبط للجاما سيكريتاز

  • GC17791 structure
    GC17791LY2811376
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  • GC19290 structure
    GC19290PF-3084014
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    Purity: >98.00%

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  • GC30427 structure
    GC30427ELN 318463 racemate
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    Purity: >98%

    زملاء ELN 318463 هو زملاء ELN318463.

  • GC30887 structure
    GC30887NGP555
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    Purity: >98.00%

    NGP555 هو مُعدِّل γ-secretase

  • GC30954 structure
    GC30954Itanapraced (CHF5074)
    CAS: 749269-83-8
    Purity: >98.00%

    Itanapraced (CHF5074) (CHF5074) هو γ جديد ؛ -مُحَوِّل secretase ، يقلل Aβ ؛ 42 و Aβ ؛ 40 إفراز ، مع IC50 من 3.6 و 18.4 μ ؛ M ، على التوالي.

  • GC31012 structure
    GC31012BMS 433796
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    Purity: >98%

    BMS 433796 هو مثبط γ- سيريز مع نشاط Aβ المنخفض في نموذج فأر معدّل وراثيًا لمرض الزهايمر