Bevirimat (Synonyms: 3-O-(3',3'-Dimethylsuccinyl) Betulinic Acid, Bevirimat, FH11327, MPC-4326) |
| رقم الكتالوجGC35508 |
Bevirimat (PA-457 ؛ MPC-4326 ؛ YK FH312) هو دواء مضاد لفيروس نقص المناعة البشرية مشتق من مركب شبيه بحمض البتيولينيك ؛ يُعتقد أنه يثبط فيروس نقص المناعة البشرية من خلال آلية جديدة تسمى تثبيط النضج
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 174022-42-5
Sample solution is provided at 25 µL, 10mM.
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Bevirimat (PA-457; MPC-4326; YK FH312) is an anti-HIV drug derived from a betulinic acid-like compound; is believed to inhibit HIV by a novel mechanism, so-called maturation inhibition.
[1]. Smith PF, et al. Phase I and II study of the safety, virologic effect, and pharmacokinetics/pharmacodynamics of single-dose 3-o-(3',3'-dimethylsuccinyl)betulinic acid (bevirimat) against human immunodeficiency virus infection. Antimicrob Agents Chemother. 2007 Oct;51(10):3574-81. [2]. Salzwedel K, et al. Maturation inhibitors: a new therapeutic class targets the virus structure. AIDS Rev. 2007 Jul-Sep;9(3):162-72. [3]. Martin DE, et al. Bevirimat: a novel maturation inhibitor for the treatment of HIV-1 infection. Antivir Chem Chemother. 2008;19(3):107-13.
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