BPR1K871 (Synonyms: DBPR114) |
| رقم الكتالوجGC35545 |
BPR1K871 هو مثبط قوي وانتقائي FLT3 / AURKA مزدوج مع IC50s من 19 نانومتر و 22 نانومتر لـ FLT3 و AURKA ، على التوالي ، يعمل كمرشح للتطور قبل السريري للعلاج المضاد للسرطان
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2443767-35-7
Sample solution is provided at 25 µL, 10mM.
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BPR1K871 is a potent and selective dual FLT3/AURKA inhibitor with IC50s of 19 nM and 22 nM for FLT3 and AURKA, respectively, acts as a preclinical development candidate for anti-cancer therapy[1]. IC50: 19 nM (FLT3), 22 nM (AURKA)[1]
BPR1K871 shows potent anti-proliferative activities in MOLM-13 and MV4-11 AML cells with an EC50 of ~ 5 nM[1].
BPR1K871 is a multi-kinase inhibitor for the treatment of acute myeloid leukemia (AML) and solid tumors[1].
[1]. Hsu YC, et al. Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation. 2016 Dec 27; 7(52): 86239-86256.
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