CI 972 (anhydrous) |
| رقم الكتالوجGC35693 |
CI 972 (لا مائي) هو مثبط قوي ، فعال عن طريق الفم ، وتنافسي من فوسفوريلاز نيوكليوزيد البيورين (PNP) (Ki \u003d 0.83 ميكرومتر) قيد التطوير كعامل مثبط للمناعة انتقائي للخلايا التائية.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 115787-68-3
Sample solution is provided at 25 µL, 10mM.
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CI 972 anhydrous is a potent, orally active, and competitive inhibitor of purine nucleoside phosphorylase (PNP) (Ki=0.83 μM) under development as a T cell-selective immunosuppressive agent[1][2]. Ki: 0.83 μM (PNP)[1]
CI 972 anhydrous (5-150 mg/kg; p.o.) produces dose-dependent elevation of plasma inosine one hour after administration to rats[1].
[1]. Gilbertsen RB, et al. Biochemical and pharmacological properties of CI-972, a novel 9-deazaguanine analog purine nucleoside phosphorylase (PNP) inhibitor. Adv Exp Med Biol. 1991;309A:41-4. [2]. Gilbertsen RB,et al. Selective in vitro inhibition of human MOLT-4 T lymphoblasts by the novel purine nucleoside phosphorylase inhibitor, CI-972. Biochem Biophys Res Commun. 1991 Aug 15;178(3):1351-8.
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