Sodium 1-hydroxypropane-1,2,3-tricarboxylate hydrate is a key intermediate in the tricarboxylic acid (TCA) cycle, serving as a reaction substrate for determining the activity of isocitrate dehydrogenase[1]. Sodium 1-hydroxypropane-1,2,3-tricarboxylate hydrate is also commonly used as a diagnostic biomarker for various cancers[2].
References:
[1] Herold RA, Reinbold R, Schofield CJ, et al. NADP(H)-dependent biocatalysis without adding NADP(H). Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2214123120.
[2] Yang Q, Sun Q, Zhang Y, et al. A multi-stage metabolic pattern of adrenocortical adenomas offers diagnostic potential of uric acid, isocitric acid, and proline. Metabolomics. 2025 Jun 22;21(4):89.