GIPR antagonist 1 is a GIPR antagonist with an IC50 of 4.8 nM. GIPR antagonist 1 inhibits glucose-dependent insulinotropic polypeptide receptor signaling. GIPR antagonist 1 can be used for the research of type 2 diabetes and obesity [1].
In Vitro, GIPR antagonist 1 (Compound 27) (10-100 nM, 6 h) antagonizes human GIPR and inhibits downstream cAMP production in a concentration‑dependent manner in CHO‑K1 cells stably expressing human GIPR[1].
References:
[1]. Kevin James Filipski, et al. Glucose-dependent insulinotropic polypeptide receptor antagonists and uses thereof. WO2024214038A1. 2025-10-14
In Vitro, GIPR antagonist 1 (Compound 27) (10-100 nM, 6 h) antagonizes human GIPR and inhibits downstream cAMP production in a concentration‑dependent manner in CHO‑K1 cells stably expressing human GIPR[1].
References:
[1]. Kevin James Filipski, et al. Glucose-dependent insulinotropic polypeptide receptor antagonists and uses thereof. WO2024214038A1. 2025-10-14