m7(3'OMeG)(5')ppp(5')(2'OMeA)pG is a co-transcriptional capping reagent that can produce Cap 1 structure with a capping efficiency of up to 98%. m7(3'OMeG)(5')ppp(5')(2'OMeA)pG needs to be used with a specific 5' AG 3' start sequence.
Compared with Cap 0 structure (ARCA and mCap capping), mRNA with Cap 1 structure is more suitable for mammalian systems and has higher transcription and translation efficiency. It is often used in protein production, RNA therapy and vaccine research.