H-Phe (3-CF3)-OH is a phenylalanine derivative targeting the L-type amino acid transporter 1 ( LAT1, SLC7A5 ) as its core target, and it belongs to LAT1 substrates. H-Phe (3-CF3)-OH can be used for prodrug scaffold development and research related to multiple solid tumors [1].
In Vitro, H-Phe (3-CF3)-OH (Compound 66) acts as a substrate of human LAT1 in induced TREx HEK-hLAT1 cells, with a relative exchange efflux rate of 59% vs L-phenylalanine, and inhibits [3H]-gabapentin uptake by 87% at 200 μM[1].
References:
[1]. Chien HC, et al. Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1). J Med Chem. 2018;61(16):7358-7373.
In Vitro, H-Phe (3-CF3)-OH (Compound 66) acts as a substrate of human LAT1 in induced TREx HEK-hLAT1 cells, with a relative exchange efflux rate of 59% vs L-phenylalanine, and inhibits [3H]-gabapentin uptake by 87% at 200 μM[1].
References:
[1]. Chien HC, et al. Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1). J Med Chem. 2018;61(16):7358-7373.