HDHD4-IN-1 (compound 3) is a N-acetylneuraminate-9-phosphate phosphatase ( HDHD4 ) inhibitor ( IC50 =11 μM). HDHD4-IN-1 can be used in the study of neurological diseases [1].
References:
[1]. Kim S H, et al. Design, synthesis, functional and structural characterization of an inhibitor of N-acetylneuraminate-9-phosphate phosphatase: Observation of extensive dynamics in an enzyme/inhibitor complex[J]. Bioorganic & medicinal chemistry letters, 2013, 23(14): 4107-4111.
References:
[1]. Kim S H, et al. Design, synthesis, functional and structural characterization of an inhibitor of N-acetylneuraminate-9-phosphate phosphatase: Observation of extensive dynamics in an enzyme/inhibitor complex[J]. Bioorganic & medicinal chemistry letters, 2013, 23(14): 4107-4111.