Hexahydrohippuric acid is a derivative of the amino acid glycine.1 It has been found in mammalian urine and is formed by gut microbiota from shikimic acid derived from plants in the diet followed by conjugation to glycine.1 Hexahydrohippuric acid is also a metabolite of cyclohexanecarboxylate, which is also a product of shikimate metabolism.2
1.Balba, M.T., and Evans, W.C.The origin of hexahydrohippurate (cyclohexanoylglycine) in the urine of herbivoresBiochem. Soc. Trans.5(1)300-302(1977) 2.Brewster, D., Jones, R.S., and Parke, D.V.The metabolism of cyclohexanecarboxylate in the ratBiochem. J.164(3)595-600(1977)