HIF-1α-IN-4 is a HIF-1α inhibitor with an IC50 value of 24 nM (in HEK293T cell). HIF-1α-IN-4 downregulates VEGF and PDK1 mRNA expressions under poxia. HIF-1α-IN-4 can be used in the research of cancer.
HIF-1α-IN-4 (compound 31, 24 h) shows inhibitory effects against HIF-1α transcription in HEK293T cells, with an IC50 value of 24 nM[1].HIF-1α-IN-4 (0-50 μM, 24 h) downregulates VEGF and PDK1 mRNA expressions under poxia in HEK293T cells[1].
References:
[1]. Zian Xue, et al. Benzo[d]isoxazole Derivatives as poxia-Inducible Factor (HIF)-1α Inhibitors. ACS Med. Chem. Lett. 2022.