HL2-m5 is the inhibitor for the interaction between sonic hedgehog/patched (Shh/PTCH1) with K d of 170 nM for Shh. HL2-m5 inhibits activation of Hedgehog signaling pathway and transcription of Gli -controlled gene with an IC50 of 230 nM [1].
References:
[1]. Owens AE, et al., Design and Evolution of a Macrocyclic Peptide Inhibitor of the Sonic Hedgehog/Patched Interaction. J Am Chem Soc. 2017 Sep 13;139(36):12559-12568.
References:
[1]. Owens AE, et al., Design and Evolution of a Macrocyclic Peptide Inhibitor of the Sonic Hedgehog/Patched Interaction. J Am Chem Soc. 2017 Sep 13;139(36):12559-12568.