HTS10307 is a small molecule AP1 Transcription Factor ΔFOSB inhibitor. HTS10307 inhibits the binding of ΔFOSB/JUND and ΔFOSB to DNA with IC50 values of ~3 μM and ~7 μM, respectively. HTS10307 can be used as a chemical probe for investigating the role of ΔFOSB in pathological conditions such as drug addiction, Alzheimer’s disease, and Parkinson’s disease [1].
References:
[1]. Sean McNeme, et al. Discovery of Small Molecules and a Druggable Groove That Regulate DNA Binding and Release of the AP1 Transcription Factor ΔFOSB. bioRxiv. October 23, 2025.
References:
[1]. Sean McNeme, et al. Discovery of Small Molecules and a Druggable Groove That Regulate DNA Binding and Release of the AP1 Transcription Factor ΔFOSB. bioRxiv. October 23, 2025.