NIC-iPSMA TFA is a ligand for molecular imaging of tumors. nic-ipsma consists of two components: NIC (6-drazinonicotinamide) and iPSMA (Inhibitor of Prostate-Specific Membrane Antigen). NIC is a compound used to attach radioactive isotopes to targeted molecules. iPSMA is a specific inhibitor used to inhibit prostate-specific membrane antigen (PSMA). 68GA-labeled iPSMA has been used to detect prostate cancer by PET imaging. The further 99mTc-EDDA/NIC-iPSMA TFA has excellent specificity and sensitivity.
References:
[1]. Ferro-Flores G, et al. Clinical translation of a PSMA inhibitor for 99mTc-based SPECT. Nucl Med Biol. 2017 May;48:36-44.