ICG-azide, a near infrared (NIR) fluorescent dye, is a copper (I)-catalyzed azide-alkyne cycloaddition (CuAAC) reagent. ICG-azide can be readily incorporated into dye-stabilized nanoemulsions and facilitate the attachment of targeting ligands via click-chemistry in a simple, scalable, and reproducible reaction.
References:
[1]. Amirshaghaghi A, et, al. Site-Specific Labeling of Cyanine and Porprin Dye-Stabilized Nanoemulsions with Affibodies for Cellular Targeting. J Am Chem Soc. 2018 Oct 24;140(42):13550-13553.
[2]. Singh S, et, al. Size-tunable ICG-based contrast agent platform for targeted near-infrared photoacoustic imaging. Photoacoustics. 2022 Dec 11:29:100437.