Influenza Hemagglutinin (HA) Peptide (Synonyms: H-Tyr-Pro-Tyr-Asp-Val-Pro-Asp-Tyr-Ala-OH) |
رقم الكتالوجGP10152 |
ببتيد
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Cas No.: 92000-76-5
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
تم استخدام علامة HA والمجمعات التي تحتوي على دنا البلازميد، ورابطات نقلفيرين-بوليلسين، وببتيدات مرتبطة بالبوليلسين المستمدة من تسلسل N-الأحادية لوحدة HA-2 في جزء هاغغلوتنان الإنفلونزا لإجراء نقل الجينات المؤشرة للاكسيراس أو -غالاكتوزيدي إلى خلايا K562 ، HeLa cells ، BNL CL.2 hepatocytes. يجعل وجود هذه الصور المرافقة لـ peptide conjugates في المجمعات DNA هذه فعَّالًا في اضطراب الغشاء في اختبار تسرُّب liposome و يؤدي إلى زيادة كبيرة في نقْلِ gene transfer بواسطَة transferrin-polylysine.
peptides Fusogenic المستمدَّة من التسلسِل N-terminal of the influenza virus hemagglutinin subunit HA-2 جزء من مجمعات DNA، مُؤديًا إلى زِیادَۃ نقْﻝِ gene transfer to cultured cells1.
فى ﻣﺎ يتعلق بفيروس الإنفلونزا، تؤدي بروتين هاغغلوتنان (HA) إلى ربط الفيروس بسطح الخلية والدمج المتزامِن لأغشية الفيروس والخلايا. يتكوَّن HA من جزء مربط لمستقبِلات، يُعرَّف باسم HA1 ، وجزء دافع لأغشية، يُعرَّف باسم HA2. المجمْع التابِع لـ HA1yHA2 في حالة عدم التصاقه على سطح الڤيرُوْس غير قادر على التصاقه. فى فيروس الإنﻓﻼﻭﻧﺲ، تُضبِط اختلافات أغشية خلايا ﺍﻟـ endosome cellular نظام اختلاف شكل بروتين hemagglutinin (HA) ، حيث يتحول من هیکل أصيل (nonfusogenic) إلى شكل نشط في دورة fusion-active (fusogenic) عند تعرضه لظروف حامضیة.
References:
1. E. WAGNER, C. PLANK et al, Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: Toward a synthetic virus-like gene-transfer vehicle. Proc. Nati. Acad. Sci. USA Vol. 89, pp. 7934-7938, September 1992
2. C. M. CARR, C. CHAUDHRY, P. S. KIM et al. Influenza hemagglutinin is spring-loaded by a metastable native conformation. Proc. Natl. Acad. Sci. USA Vol. 94, pp. 14306–14313
Cas No. | 92000-76-5 | SDF | |
المرادفات | H-Tyr-Pro-Tyr-Asp-Val-Pro-Asp-Tyr-Ala-OH | ||
Chemical Name | Influenza Hemagglutinin (HA) Peptide | ||
Canonical SMILES | CC(C)C(C(=O)N1CCCC1C(=O)NC(CC(=O)O)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(C)C(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C4CCCN4C(=O)C(CC5=CC=C(C=C5)O)N | ||
Formula | C53H67N9O17 | M.Wt | 1102.15 |
الذوبان | ≥55.1075mg/mL in DMSO, ≥100.4 mg/mL in EtOH, ≥46.2 mg/mL in Water | Storage | Desiccate at -20°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
1 mg | 5 mg | 10 mg | |
1 mM | 0.9073 mL | 4.5366 mL | 9.0732 mL |
5 mM | 0.1815 mL | 0.9073 mL | 1.8146 mL |
10 mM | 0.0907 mL | 0.4537 mL | 0.9073 mL |
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
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