Iptocigistat (Iptocigistatum) is a cyclic GMP-AMP synthase ( cGAS ) inhibitor. Iptocigistat prevents excessive immune responses. Iptocigistat can be used to study inflammation-related autoimmune diseases [1].
In Vitro, Iptocigistat (Compound 10) inhibits the activity of human guanylate-adenylate cyclase in a cell-free Kinase-Glo assay, with an IC50 ranging from ≥0.005 μM to <0.02 μM[1]. Iptocigistat inhibits the activity of human guanylate-adenylate synthase in cell-free LCMS assays, with an IC50 of ≥0.005 μM and <0.02 μM[1].
References:
[1]. Ramsay Beveridge, et al. Thiadiazole derivatives as inhibitors of cyclic gmp-amp synthase and uses thereof. WO2024137607A1. 2025-06-20
In Vitro, Iptocigistat (Compound 10) inhibits the activity of human guanylate-adenylate cyclase in a cell-free Kinase-Glo assay, with an IC50 ranging from ≥0.005 μM to <0.02 μM[1]. Iptocigistat inhibits the activity of human guanylate-adenylate synthase in cell-free LCMS assays, with an IC50 of ≥0.005 μM and <0.02 μM[1].
References:
[1]. Ramsay Beveridge, et al. Thiadiazole derivatives as inhibitors of cyclic gmp-amp synthase and uses thereof. WO2024137607A1. 2025-06-20