Isodeoxycholic Acid is a secondary bile acid [1]. Isodeoxycholic Acid regulates bile acid synthesis, enterohepatic circulation, and energy metabolism, influencing the composition of the intestinal microbiome and inflammatory responses [2]. Isodeoxycholic Acid is primarily used to treat cholestasis, hepatobiliary diseases, and metabolic syndrome [3-4].
In CD4⁺T cells, Isodeoxycholic Acid (100μM; 3d) acts on dendritic cells, weakening their immunostimulatory properties and thereby enhancing the induction of Foxp3 [5].
References:
[1]. Marschall H U, Broomé U, Einarsson C, et al. Isoursodeoxycholic acid: metabolism and therapeutic effects in primary biliary cirrhosis 1[J]. Journal of Lipid Research, 2001, 42(5): 735-742.
[2]. Devlin A S, Fischbach M A. A biosynthetic pathway for a prominent class of microbiota-derived bile acids[J]. Nature chemical biology, 2015, 11(9): 685-690.
[3]. Hofmann A F, Hagey L R. Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics[J]. Cellular and Molecular Life Sciences, 2008, 65(16): 2461-2483.
[4]. Pabst O, Hornef M W, Schaap F G, et al. Gut–liver axis: barriers and functional circuits[J]. Nature Reviews Gastroenterology & Hepatology, 2023, 20(7): 447-461.
[5]. Campbell C, McKenney P T, Konstantinovsky D, et al. Bacterial metabolism of bile acids promotes peripheral Treg cell generation[J]. Nature, 2020, 581(7809): 475.