K67 |
| رقم الكتالوجGC66004 |
K67 يمنع على وجه التحديد التفاعل بين Keap1 و S349-phosphorylated p62. يمنع K67 p-p62 من حظر ربط Keap1 و Nrf2. يمنع K67 بشكل فعال تكاثر ثقافات HCC مع P62 الخلوي عالي الفسفرة S351 من خلال استعادة انتشار Nrf2 وتدهوره بواسطة Keap1.
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Cas No.: 2046250-48-8
Sample solution is provided at 25 µL, 10mM.
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K67 specifically inhibits the interaction between Keap1 and S349-phosphorylated p62. K67 prevents p-p62 from blocking the binding of Keap1 and Nrf2. K67 effectively inhibits the proliferation of HCC cultures with high cellular S351-phosphorylated p62 by restoring the ubiquitination and degradation of Nrf2 driven by Keap1[1].
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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