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Kendomycin (Synonyms: TAN 2162)

رقم الكتالوجGC18501 Copy One-Click Copy Product Info

Kendomycin ((-) - TAN 2162) هو مضاد حيوي بوليكيتيد مع أنشطة ملحوظة مضادة للجراثيم وخلايا سرطانية سامة للخلايا

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Kendomycin التركيب الكيميائي

Cas No.: 183202-73-5

الحجم السعر المخزون الكميّة
500μg
337٫00
متوفر
100μg
125٫00
متوفر

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مراجعات العميل

بناء على آراء العملاء.

Sample solution is provided at 25 µL, 10mM.



Description of Kendomycin

Kendomycin is a macrolide from Streptomyces which displays potent cytotoxicity against several carcinoma cell lines (GI50 < 100 nM). It also acts as an endothelin receptor antagonist and has antiosteoporotic activities. Certain effects are thought to be mediated through inhibition of proteasomal degradation of proteins.

Chemical Properties of Kendomycin

Cas No. 183202-73-5 SDF
المرادفات TAN 2162
Chemical Name (13E)-6R,7S,8R,9R,10,11,12S,15,16S,17,18S,19S-dodecahydro-4,7,19-trihydroxy-2,6,8,12,14,16,18-heptamethyl-1,19:5R,9-diepoxybenzocyclooctadecen-3(5H)-one
Canonical SMILES C[C@@H](CC[C@]1([H])[C@H](C)[C@H](O)[C@@H](C)[C@](O1)([H])C2=C(O)C3=O)/C=C(C[C@@H](C)C[C@H](C)[C@@]4(O)C=C2C(O4)=C3C)\C
Formula C29H42O6 M.Wt 486.6
الذوبان Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Kendomycin

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.0551 mL 10.2754 mL 20.5508 mL
5 mM 411 μL 2.0551 mL 4.1102 mL
10 mM 205.5 μL 1.0275 mL 2.0551 mL
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In vivo Formulation Calculator (Clear solution) of Kendomycin

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % saline
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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Average Rating: 5 ★★★★★ (Based on Reviews and 1 reference(s) in Google Scholar.)

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