KTX-582 intermediate-2

KTX-582 intermediate-2 is an intermediate in the synthesis of KTX-582 and can be used for ADC preparation. KTX-582 is an IRAK4 degrader and inducer of apoptosis with DC_{50 of 4 nM and 5 nM for IRAK4 and Ikaros, respectively^[1].}

References:
[1]. Mainolfi, et al. Preparation of heterocycles as IRAK degraders and uses thereof. World Intellectual Property Organization, WO2022147465 A1. 2022-07-07.