Lumasiran (Synonyms: ALN-G01) |
| رقم الكتالوجGC64379 |
يقلل لوماسيران (ALN-G01)، المنتج الذي يعتمد على RNAi، إنتاج أكسالات الكبد عن طريق استهداف أوكسيديز الغلايكولات.
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Cas No.: 1834610-13-7
Sample solution is provided at 25 µL, 10mM.
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Lumasiran (ALN-G01), a siRNA product, reduces hepatic oxalate production by targeting glycolate oxidase. By silencing the gene encoding glycolate oxidase, Lumasiran depletes glycolate oxidase and thereby inhibits the synthesis of oxalate, which is the toxic metabolite that is directly associated with the clinical manifestations of Primary hyperoxaluria type 1 (PH1)[1][2].
Lumasiran reduced urinary oxalate excretion, the cause of progressive kidney failure in PH1[1].
Lumasiran sodium is a subcutaneously administered, liver-directed RNA interference (RNAi) therapeutic agent[2].
[1]. Scott LJ, et al. Lumasiran: First Approval. Drugs. 2021;81(2):277-282.
[2]. Garrelfs SF, et al. Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1. N Engl J Med. 2021;384(13):1216-1226.
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