LY-266500 is a succinyl CoA synthetase (SCS) specific inhibitor. LY-266500 has inhibitory effects on various parasites, such as Trypanosoma brucei brucei ( IC50 =0.6 μM) and Leishmania donovani ( IC50 =2.86 μM). LY-266500 can be used for research on parasitic infections [1].
References:
[1]. Hunger-Glaser I, et al. Inhibition of succinyl CoA synthetase histidine-phosphorylation in Trypanosoma brucei by an inhibitor of bacterial two-component systems. Mol Biochem Parasitol. 1999 May 15;100(1):53-9.
References:
[1]. Hunger-Glaser I, et al. Inhibition of succinyl CoA synthetase histidine-phosphorylation in Trypanosoma brucei by an inhibitor of bacterial two-component systems. Mol Biochem Parasitol. 1999 May 15;100(1):53-9.