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MDM2

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The murine double minute 2 (MDM2) is a protein encoded by the mdm2 gene that functions as an E3 ubiquitin ligase to ubiquitinate the p53 tumor suppressor and promotes the proteasomal degradation of p53. Human MDM2 protein is a phosphoprotein of 491 amino acids that inherits the E3 ubiquitin ligase activity from its evolutionarily conserved COOH terminal of RING finger domain (Zinc-binding), a common motif in E3 ligases. Human MDM2 protein mediates monomeric ubiquitination on multiple lysine residues mainly in the COOH terminus of p53 and directly inhibits the transcriptional activity of p53 through binding to the NH2 terminal transactivation domain of p53.

Products Related to MDM2(12)

  • GC12508 structure
    GC12508Nutlin-3b
    CAS: 675576-97-3
    Purity: >98.00%

    Nutlin-3b هو مثبط p53 / MDM2 مع IC من 13.6 ميكرومترNutlin-3b هو 150 مرة أقل قوة في الارتباط بـ MDM2 من Nutlin-3a

  • GC10022 structure
    GC10022SP 141
    CAS: 1253491-42-7
    Purity: >99.00%

    SP 141 هو مثبط محدد لـ MDM2. يعزز SP 141 التواجد الذاتي لـ MDM2 وتدهوره. يمكن استخدام SP 141 للبحث عن سرطان البنكرياس وخلايا سرطان الثدي.

  • GC11547 structure
    GC11547MI-773 (SAR405838)
    CAS: 1303607-60-4
    Purity: >98.00%

    MI-773 (SAR405838) (MI-77301) ، نظير MI-773 ، هو مثبط تفاعل MDM2-p53 شديد الفعالية وانتقائي. يرتبط MI-773 (SAR405838) بـ MDM2 مع Ki يبلغ 0.88 نانومتر. يستحث MI-773 (SAR405838) موت الخلايا المبرمج وله نشاط قوي مضاد للأورام.

  • GC11594 structure
    GC11594RG7388
    CAS: 1229705-06-9
    Purity: >99.50%

    RG7388 is an orally active MDM2 antagonist (IC 50 =6nM) that activates the p53 pathway by inhibiting the MDM2-p53 interaction.

  • GC12117 structure
    GC12117JNJ-26854165 (Serdemetan)
    CAS: 881202-45-5
    Purity: >99.00%

    An antagonist of MDM2 action

  • GC12701 structure
    GC12701NSC 207895 (XI-006)
    CAS: 58131-57-0
    Purity: >98.00%

    An inhibitor of MDMX

  • GC12793 structure
    GC12793RITA (NSC 652287)
    CAS: 213261-59-7
    Purity: >99.00%

    RITA (NSC 652287) is a tricyclic thiophene derivative that binds to p53dN (K d =1.5nM) and blocks the p53-HDM-2 interaction, thereby inhibiting p53 ubiquitination.

  • GC13019 structure
    GC13019RG7112
    CAS: 939981-39-2
    Purity: >99.50%

    An inhibitor of the MDM2-p53 interaction

  • GC13687 structure
    GC13687NSC 66811
    CAS: 6964-62-1
    Purity: >98.00%

    A potent inhibitor of Mdm2-p53 interaction

  • GC14154 structure
    GC14154(±)-Nutlin-3
    CAS: 548472-68-0
    Purity: >99.00%

    (±)-Nutlin-3 is a potent and selective MDM2 antagonist with IC 50 value of 0.09μM.

  • GC17262 structure
    GC17262Pifithrin-β
    CAS: 60477-34-1
    Purity: >98.00%

    Pifithrin-β (PFT β) هو مثبط قوي p53 مع IC 50 من 23 ميكرومتر

  • GC11445 structure
    GC11445YH239-EE
    CAS: 1364488-67-4
    Purity: >99.50%

    YH239-EE ، إيثيل إستر لمركب حمض الكربوكسيل الحر YH239 ، هو عامل مضاد ومحفز لموت الخلايا المبرمج p53-MDM2