MNK inhibitor 9 is a potent and selective inhibitor of MNK1/2 with IC50 values of 0.003 ?M and 0.003 ?M for MNK1 and MNK2 respectively. MNK inhibitor 9 has good cell permeability. MNK inhibitor 9 can be used in tumor related research[1].
References:
[1]. Han W, et al. Discovery of a Selective and Potent Inhibitor of Mitogen-Activated Protein Kinase-Interacting Kinases 1 and 2 (MNK1/2) Utilizing Structure-Based Drug Design. J Med Chem. 2016 Apr 14;59(7):3034-45.