MnTE-2-PyP (BMX-010) chloride is a ROS scavenger and potent radioprotector. MnTE-2-PyP also is a manganese porprin, protects normal prostate tissue from radiation damage. MnTE-2-PyP can be used for the research of diabetic prostate cancer.
MnTE-2-PyP (30 μM) protects against perglycemiainduced cell death after radiation[1]. MnTE-2-PyP (30 μM) decreases expression of NOX4 and a-SMA, one of the major oxidative enzymes and pro-fibrotic molecules respectively[1]. MnTE-2-PyP (30 μM, 5 days) obstructs NF-kB activity by decreasing DNA binding of the p50-p50 homodimer in the irradiated perglycemic environment[1]. MnTE-2-PyP (30 μM) increases NRF2 mediated cytoprotection by increasing NRF2 protein expression and DNA binding[1].
MnTE2-PyP decreases tumor volume and increases survival in vivo mouse model of prostate cancer[1]. MnTE-2-PyP reduces blood glucose and inhibits pro-fibrotic signaling in a diabetic model[1].
References:
[1]. Arpita Chatterjee, et al. MnTE-2-PyP, a manganese porprin, reduces cytotoxicity caused by irradiation in a diabetic environment through the induction of endogenous antioxidant defenses. Redox Biol. 2020 Jul;34:101542.