NCATS-SM7270 is a highly specific NOX2 inhibitor, with an IC50 of 4.09 μM. NCATS-SM7270 protects mice from mild traumatic brain injury [1].
References:
[1]. Mason H, et al. Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury. Redox Biol. 2023 Apr;60:102611.
References:
[1]. Mason H, et al. Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury. Redox Biol. 2023 Apr;60:102611.
















