Neuroendocrinology

Octreotide is a somatostatin analogue, which can bind to somatostatin receptor. It mainly has 2, 3 and 5 subtypes, which can enhance GI activity and reduce intracellular cAMP production

ACTH (6-24) is a peptide fragment of adrenocorticotropic hormone, a peptide hormone found in the brain that is involved in the biological stress response.

Ghrelin is an endogenous gastrointestinal hormone and neuropeptide that binds to the growth hormone (GH) secretagogue receptor (GHS-R).

3-Iodothyronamine is derived from the deiodination and decarboxylation of endogenous thyroxine.

Adrenomedullin (22-52) is a C-terminal fragment of adrenomedullin (1-52).

Amylin (8-37) is a peptide fragment of amylin.

Amylin is a peptide hormone secreted from pancreatic β-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety.

Amylin is a 37-residue peptide hormone secreted from pancreatic β-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety.

Arginine vasotocin is a nonapeptide hormone agonist of the AVT receptor (EC50 = 13 nM for eliciting membrane currents in X.

Benzomalvin C is a weak antagonist of the neurokinin-1 (NK1) receptor inhibiting binding of substance P by 46% when used at 100 μg/ml in vitro.

Caerulein is an oligopeptide originally isolated from skin extracts of H.

Cholecystokinin (CCK) octapeptide is a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety.

Cortistatin-14 is an endogenous neuropeptide agonist of somatostatin receptors (IC50s = 0.5-18.2 nM for human SST1-SST5 receptors expressed in CCL39 cells).

Cyclic ADP-ribose (cADP-ribose) is an endogenous metabolite of NAD+ that mobilizes the release of stored Ca2+ in the endoplasmic reticulum via ryanodine receptors in various cell types.

Dynorphin B (1-9) is a neuropeptide and N-terminal cleavage product of dynorphin B, an endogenous opioid.

Galanin is a neuropeptide with diverse biological activities.

Ghrelin is an endogenous gastrointestinal hormone and neuropeptide that binds to the growth hormone (GH) secretagogue receptor (GHS-R).

Ghrelin is an endogenous gastrointestinal hormone and neuropeptide that binds to the growth hormone (GH) secretagogue receptor (GHS-R).

Gonadotropin releasing hormone (GnRH) is a peptide hormone produced in the hypothalamus that is secreted in a pulsatile fashion and stimulates the release of luteinizing hormone and follicle-stimulating hormone.

Gonadotropin-releasing hormone II (GnRH II) is a peptide agonist of the GnRH receptor (GnRHR).

Melanin-concentrating hormone (MCH) is an endogenous hypothalamic neuropeptide hormone that is an agonist at MCH receptors.

Metanephrine is a metabolite of epinephrine produced by the action of catechol-O-methyl transferase on epinephrine.

Neuromedin B (NMB) is a peptide agonist of the NMB receptor (Ki = 7.4 nM in NCI-H1299 small cell lung cancer cells expressing the human receptor).

Neuromedin S is a neuropeptide agonist of the neuromedin U (NMU) receptors that increases calcium concentrations in CHO cells overexpressing NMU1 and NMU2 (EC50s = 65 and 91 pM, respectively).