Niranthin |
رقم الكتالوجGC17997
One-Click Copy Product Info
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Niranthin ، قشور مع مجموعة واسعة من الأنشطة الدوائية
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 50656-77-4
Sample solution is provided at 25 µL, 10mM.
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IC50: 15.6 μM and 25.1 μM for inhibiting the secretion of HBsAg and HBeAg, respectively.
Niranthin is a natural lignin isolated from the genus Phyllanthus, with antiviral activities both in vitro and in vivo. Niranthin also exerts anti-inflammatory and anti-allodynic activities.
In Vitro: In human hepatoma cell line MS-G2 which synthesizes hepatitis B viral particles, Niranthin was screened among 25 pure compounds which were isolated from several phyllanthus species with the most potent anti-HBV activity (EC50= 33.6 μM) by effectively suppressing the expression of HBsAg and HBeAg, with the highest inhibition of 74.3% [1]. Besides, in human HBV-transfected liver cell line HepG2.2.15, Niranthin could significantly inhibit the secretion of HBsAg and HBeAg after treatment for 144 h, with the IC50 values of 15.6 μM and 25.1 μM, respectively [2].
In Vivo: In duck hepatitis B virus (DHBV) infected ducks, intragastric administration of Niranthin could significantly decrease the plasma DHBV DNA levels, with the mean inhibition percentage of 70.72%, 75.23%, and 90.87% at the dose of 25, 50, and 100 mg/kg/day, respectively. Niranthin could also significantly inhibit the serum HBsAg, HBeAg, ALT, and AST levels [2].
Clinical trial: no data available.
References:
[1] Huang R, Huang Y, Ou J, et al. Screening of 25 compounds isolated from Phyllanthus species for anti-human hepatitis B virus in vitro[J]. Phytotherapy Research, 2003, 17(5): 449-453.
[2] Liu S, Wei W, Li Y, et al. In vitro and in vivo anti-hepatitis B virus activities of the lignan nirtetralin B isolated from Phyllanthus niruri L.[J]. Journal of Ethnopharmacology, 2014, 157(2): 1061-1067.
| Cas No. | 50656-77-4 | SDF | |
| Chemical Name | rel-6-[(2R,3R)-4-(3,4-dimethoxyphenyl)-2,3-bis(methoxymethyl)butyl]-4-methoxy-1,3-benzodioxole | ||
| Canonical SMILES | COC1=CC(C[C@@H](COC)[C@H](COC)CC2=CC(OC)=C(OC)C=C2)=CC3=C1OCO3 | ||
| Formula | C24H32O7 | M.Wt | 432.5 |
| الذوبان | DMF: 15 mg/ml,DMSO: 10 mg/ml,Ethanol: 5 mg/ml | Storage | Store at -20°C,protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.3121 mL | 11.5607 mL | 23.1214 mL |
| 5 mM | 462.4 μL | 2.3121 mL | 4.6243 mL |
| 10 mM | 231.2 μL | 1.1561 mL | 2.3121 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)