NS 3861 |
| رقم الكتالوجGC50079 |
NS 3861 هو ناهض لمستقبلات الأسيتيل كولين النيكوتين (nAChRs) ويرتبط بتقارب كبير مع مغاير α ؛ 3β ؛ 4 nAChR.
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Cas No.: 216853-60-0
Sample solution is provided at 25 µL, 10mM.
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α3β2 full agonist (EC50 = 1.6 μM). Also α3β4 partial agonist (EC50 = 1 μM). Exhibits minimal activity at α4β2 and α4β4. Displays high affinity for α3β4, α4β4, α3β2 and α4β2 (Ki values are 0.62, 7.8, 25 and 55 nM respectively).
Harpsøe et al (2013) Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors. J.Biol.Chem. 288 2559 PMID:23229547
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)
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