o,p'-DDE (Synonyms: 2,4’-DDE, o,p'-Dichlorodiphenyldichloroethylene, NSC 59908) |
| رقم الكتالوجGC44479 |
o,p'-DDE is a metabolite and degradation product of the organochlorine pesticide DDT.
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Cas No.: 3424-82-6
Sample solution is provided at 25 µL, 10mM.
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o,p'-DDE is a metabolite and degradation product of the organochlorine pesticide DDT. It accumulates in smallmouth buffalo, channel catfish, and largemouth bass as well as sediment in the Huntsville Spring Branch-Indian Creek tributary system surrounding a DDT manufacturing plant where it is considered a persistent organic pollutant (POP). o,p'-DDE inhibits estrogen binding to rainbow trout estrogen receptors (rtERs) with an IC50 value of 3.2 μM. It induces concentration-dependent secretion of estradiol by granulosa and theca cell co-cultures isolated from porcine ovarian follicles. In ovo exposure to o,p'-DDE increases degeneration of ovarian follicles and reduces testicular size in Japanese medaka (O. latipes).
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