OAT-177 is a potent dual inhibitor targeting acidic mammalian chitinase ( AMCase ) and chitotriosidase ( CHIT1 ) with an IC50 =14.2 nM for human AMCase and IC50 =232 nM for human CHIT1. OAT-177 is promising for research of chronic inflammatory and fibrotic-related lung diseases such as asthma and idiopathic pulmonary fibrosis [1].
References:
[1]. Koralewski R, et al. Discovery of OATD-01, a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis. J Med Chem. 2020 Dec 24;63(24):15527-15540.
References:
[1]. Koralewski R, et al. Discovery of OATD-01, a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis. J Med Chem. 2020 Dec 24;63(24):15527-15540.