Peptide Coupling Reagents

TATU

HOAt is a coupling reagent that promotes peptide bond formation between carboxylic acids and amines by first reacting with the acid to generate an activated intermediate, which then reacts with the amine to form the amide.

Reagent to suppress racemization in peptide coupling, which is not toxic.

DEPBT

PyAOP is a coupling reagent used to prepare amides from carboxylic acids and amines in peptide synthesis.

used in peptide coupling chemistry

It used as dehydrating agent, or the synthesis of acid anhydride, aldehyde, ketone, isocyanate.

Peptide coupling reagent

TOTU

TDBTU

TPTU

HOBt (anhydrous) is a heterocycle most often used as a catalytic or stoichiometric agent to accelerate nucleophilic acyl substitution reactions, particularly amidations.

Reagent for activating the carboxylic group, synthesis of amides 1,2; Esters 3; Peptides 4

PyBroP is a phosphonium salt used in peptide coupling chemistry, similar to PyCloP.

HCTU is a highly efficient aminium-based coupling reagent widely utilized in solid-phase and solution-phase peptide synthesis.

TSTU

Peptide coupling reagent

TCFH

HOOBt

Used for the oxidation of hydroxychlorins to chlorin-α-diones and tetraones.