PGP-4008 |
رقم الكتالوجGC44615 |
PGP-4008 هو مثبط محدد للبروتين السكري (Pgp)يثبط PGP-4008 نمو الورم في نموذج الورم الصلب متعدد المقاومة للأدوية (MDR) الذي يتوسطه الفئران المتآكلة عند تناوله مع Doxorubicin
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Cas No.: 365565-02-2
Sample solution is provided at 25 µL, 10mM.
PGP-4008 is a selective inhibitor of P-glycoprotein (P-gp) that does not affect the activity of multidrug resistance-related protein 1 (MRP1). It is effective in vitro and, when delivered intraperitoneally, in vivo, inhibiting tumor growth when given with doxorubicin . PGP-4008 also enhances the ability of docetaxel to inhibit growth and drive apoptosis in ovarian cancer cells.
Average Rating: 5
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