Phosphatidylcholines,soya, a major class of glycerophospholipids present in cells, play critical roles in membrane structure and cellular signaling[1]. Phosphatidylcholines inhibit latex bead phagosome actin assembly, the killing of Mycobacterium tuberculosis in macrophages, and the sphingosine 1-phosphate-induced actin assembly in macrophages[2]. Phosphatidylcholines have been widely used in the preparation of various types of liposomes for controlled drug delivery of chemotherapeutics[3]. Phosphatidylcholines have been employed in the engineering of exosomes to facilitate the intracellular delivery of anti-tumor drugs and enhance tumor cell uptake[4].
References:
[1] Lordan R, Tsoupras A, Zabetakis I. Phospholipids of animal and marine origin: Structure, function, and anti-inflammatory properties[J]. Molecules, 2017, 22(11): 1964.
[2] Treede I, Braun A, Sparla R, et al. Anti-inflammatory effects of phosphatidylcholine[J]. Journal of Biological Chemistry, 2007, 282(37): 27155-27164.
[3] Gkionis L, Aojula H, Harris L K, et al. Microfluidic-assisted fabrication of phosphatidylcholine-based liposomes for controlled drug delivery of chemotherapeutics[J]. International journal of pharmaceutics, 2021, 604: 120711.
[4] Zhan Q, Yi K, Li X, et al. Phosphatidylcholine‐engineered exosomes for enhanced tumor cell uptake and intracellular antitumor drug delivery[J]. Macromolecular bioscience, 2021, 21(8): 2100042.