Platyconic Acid A is an active component of changkil saponins from platycodon grandiflorum and can be used for the research of reducing airway inflammation[1].
Platyconic Acid A (0.5~2 μM; 30 minutes; A549 cells) inhibits PMA-induced NF-κB p65 phosphorylation, IκBα phosphorylation and degradation and Akt phosphorylation in a concentration-dependent manner[1].Platyconic Acid A (0.5~2 μM; 24 hours; A549 cells) decreases PMA-increased MUC5AC mRNA expression in a concentration-dependent manner[1].
[1]. Choi JH, et al. Saponins, especially platyconic acid A, from Platycodon grandiflorum reduce airway inflammation in ovalbumin-induced mice and PMA-exposed A549 cells. J Agric Food Chem. 2015;63(5):1468-1476.