ProAX is an AXP prodrug which enhances intracellular ATP levels without inducing cytotoxicity. ProAX can be metabolized by intracellular enzymes such as esterases and phosphoamidases, resulting in the conversion to AMP, ADP, and ATP. ProAX has potential applications in the research of bioenergetic-molecule therapeutics [1].
References:
[1]. Anada T, et al. A Nucleic Acid Prodrug That Activates Mitochondrial Respiration, Promotes Stress Resilience, and Prolongs Lifespan. J Am Chem Soc. 2025 Jun 25;147(25):22161-22175.
References:
[1]. Anada T, et al. A Nucleic Acid Prodrug That Activates Mitochondrial Respiration, Promotes Stress Resilience, and Prolongs Lifespan. J Am Chem Soc. 2025 Jun 25;147(25):22161-22175.