Przewaquinone B is an abietane-type diterpene quinone (tanshinone) and a diterpenoid compound. Przewaquinone B can be isolated from the rhizomes of Salvia miltiorrhiza Bunge, the roots of Salvia przewarskii, and the roots of Salvia constanea. Przewaquinone B exhibits antitumor activity against cervical cancer and promyelocytic leukemia. Przewaquinone B can be used in research related to cervical cancer and promyelocytic leukemia [1] [2] [3].
In Vitro, Przewaquinone B exhibits weak cytotoxicity against HeLa cells (IC50 = 19.0 μM) and significant cytotoxicity against HL-60 cells (IC50 = 3.0 μM)[2].
References:
[1]. Wang X, et al. New developments in the chemistry and biology of the bioactive constituents of Tanshen. Med Res Rev. 2007 Jan;27(1):133-48.
[2]. Tsukada H, et al. Two New Diterpenoids from Salvia przewarskii. Natural product communications. 2016 Feb;11(2):159-61.
[3]. YANG M H, et al. Diterpenoids from Salvia species[J]. Pharmacy and Pharmacology Communications, 1996, 2(1): 69-71.
In Vitro, Przewaquinone B exhibits weak cytotoxicity against HeLa cells (IC50 = 19.0 μM) and significant cytotoxicity against HL-60 cells (IC50 = 3.0 μM)[2].
References:
[1]. Wang X, et al. New developments in the chemistry and biology of the bioactive constituents of Tanshen. Med Res Rev. 2007 Jan;27(1):133-48.
[2]. Tsukada H, et al. Two New Diterpenoids from Salvia przewarskii. Natural product communications. 2016 Feb;11(2):159-61.
[3]. YANG M H, et al. Diterpenoids from Salvia species[J]. Pharmacy and Pharmacology Communications, 1996, 2(1): 69-71.