الصفحة الرئيسية>>Signaling Pathways>> GPCR/G protein>> CXCR>>(R)-SCH 546738

(R)-SCH 546738

رقم الكتالوجGC72753

(R)-SCH 546738 هو R-isomer من SCH 546738.

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(R)-SCH 546738 التركيب الكيميائي

Cas No.: 2181148-54-7

الحجم السعر المخزون الكميّة
5 mg
239٫00
متوفر
10 mg
357٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of (R)-SCH 546738

(R)-SCH 546738 is the R-isomer of SCH 546738 . SCH 546738 is an orally active and non-competitive antagonist for CXCR3 with Ki of 0.4 nM for human CXCR3 receptor.

References:
[1]. Jenh CH, et al. A selective and potent CXCR3 antagonist SCH 546738 attenuates the development of autoimmune diseases and delays graft rejection. BMC Immunol. 2012 Jan 10;13:2.

Chemical Properties of (R)-SCH 546738

Cas No. 2181148-54-7 SDF
Formula C23H31Cl2N7O M.Wt 492.44
الذوبان DMSO : 12.5 mg/mL (25.38 mM; ultrasonic and warming and heat to 60°C) Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of (R)-SCH 546738

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.0307 mL 10.1535 mL 20.307 mL
5 mM 0.4061 mL 2.0307 mL 4.0614 mL
10 mM 0.2031 mL 1.0154 mL 2.0307 mL
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In vivo Formulation Calculator (Clear solution) of (R)-SCH 546738

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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