الصفحة الرئيسية>>Signaling Pathways>> GPCR/G protein>> Neurotensin Receptors>>(R)-Sortilin antagonist 1

(R)-Sortilin antagonist 1

رقم الكتالوجGC73187

(R)-Sortilin antagonist 1 هو مضاد السورتيلين الذي يمنع مسار موت الخلايا المبرمج بوسيلة السورتيلين عن طريق التدخل في ربط السورتيلين إلى ليجند برونيوتروفين.

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(R)-Sortilin antagonist 1 التركيب الكيميائي

Cas No.: 2889422-86-8

الحجم السعر المخزون الكميّة
1 mg
365٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of (R)-Sortilin antagonist 1

(R)-Sortilin antagonist 1 is a sortilin antagonist that blocks the sortilin mediated apoptosis pathway by interfering with the binding of sortilin to its ligand pro-neurotrophin. (R)-Sortilin antagonist 1 can be used in the study of hearing loss.

References:
[1]. KJØLBY Mads Fuglsang, et al. A sortilin antagonist for use in the prevention or treatment of hearing loss.WO2022074119A1.2021-10-07

Chemical Properties of (R)-Sortilin antagonist 1

Cas No. 2889422-86-8 SDF
Formula C20H24N2O4 M.Wt 356.42
الذوبان DMSO : 100 mg/mL (280.57 mM; Need ultrasonic) Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of (R)-Sortilin antagonist 1

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.8057 mL 14.0284 mL 28.0568 mL
5 mM 0.5611 mL 2.8057 mL 5.6114 mL
10 mM 0.2806 mL 1.4028 mL 2.8057 mL
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** عند إعداد حلول المخزون، دائمًا استخدم الوزن الجزيئي الخاص بالدفعة للمنتج على ملصق القارورة MSDS / CoA (متوفر عبر الإنترنت).

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In vivo Formulation Calculator (Clear solution) of (R)-Sortilin antagonist 1

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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