GPR139
GPR139 (G protein-coupled receptor 139) is a protein that in humans is encoded by the GPR139 gene. GPR139 is an orphan G-protein–coupled receptor expressed in the central nervous system.
The expression pattern of GPR139 has primarily been studied on the mRNA level and showed expression mainly in the central nervous system.
GPR139 is an orphan receptor identified from bioinformatics analysis of the human genome. GPR139 is thus a potential target for the treatment of Parkinson’s disease, obesity, eating disorders, and/or diabetes.
The GPR139 is expressed specifically in the brain in areas of relevance for motor control. GPR139 function and signal transduction pathways are elusive, and results in the literature are even contradictory. GPR139 agonists dose-dependently protect primary dopaminergic (DA) neurons against MPP+ toxicity.
أهداف لـ نبسب؛ GPR139
منتجات لـ نبسب؛ GPR139
- القط. رقم اسم المنتج بيانات
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GC71095
GPR139 agonist-2
GPR139 agonist-2 (المركب 20a) هو ناهض قوي GPR139 مع EC50 من 24.7 نانومتر.
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GC19209
JNJ-63533054
JNJ-63533054 هو محفز قوي وانتقائي للجين GPR139 البشري مع EC50 = 16nM
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GC69400
LP-471756
LP-471756 هو مضاد فعال لمستقبل GPR139 ، وقيمة IC50 الخاصة به هي 640 نانومتر. يثبط LP-471756 إنتاج cAMP المحفز بواسطة LP-360924.
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GC66431
NCRW0005-F05
NCRW0005-F05 هو ناهض GPR139 قوي بقيمة IC50 تبلغ 0.21 μ ؛ M. يمكن استخدام NCRW0005-F05 للبحث في مرض السكري والسمنة ومرض باركنسون ' ؛ ق.