Apoptosis

Haplophytin-A is a quinoline alkaloid.

OH14 is a cellular FLICE-like inhibitory protein ( cFLIP) inhibitor and TNF-related apoptosis-inducing ligand ( TRAIL ) sensitizer.

(2S,3R,4S)-ASX-173 is the (2S,3R,4S)-enantiomer of ASX-173.

TMLB-C16 is a potent and orally active B3GAT3 inhibitor with a K D of 3.962 μM.

DL78 is an effective anti-mitotic agent.

GPS167 is a CLK kinase inhibitor that potently and selectively inhibits recombinant human CLK1, CLK2 and CLK4.

MS1129 is a DNMT degrader that induces proteasomal degradation of DNMT1, DNMT3A and DNMT3B proteins.

SM-122 is a monovalent Smac mimetic targeting cellular inhibitor of apoptosis protein ( cIAP )-1/2.

ACT001 (Dimethylaminomicheliolide; DMAMCL) hydrochloride is an orally active, blood-brain barrier-permeable anti-inflammatory and anti-tumor agent.

WJH-C19 is an orally active RIPK1 inhibitor with an IC 50 of 5.7 nM.

UCI-LC0019 is a mutant p53 reactivator.

MI-773 TFA is an orally active, selective MDM2-p53 interaction inhibitor with a K i of 0.88 nM for MDM2.

HBS-101 is a selectively, orally active, brain-penetrant, Midkine (MDK) inhibitor ( K D = 38.4 nM).

EAD1 trihydrochloride is a Chloroquine analog with anticancer activity.

CTX-439 is an orally active, ATP-competitive small-molecule inhibitor of CDK12 and CDK13, with an IC 50 of 3.1 nM and a K d of 0.38 nM against CDK12, and an IC 50 of 9.2 nM against CDK13.

CID-078 is an orally active macrocyclic cyclin A and cyclin B inhibitor.

SY-589 is an orally active DNA polymerase Polθ helicase domain inhibitor ( IC 50 =2.29 nM) and DNA damage inducer.

C791-0064 is a RAD52 inhibitor.

WCY-8-67 TFA is an orally active and selective USP5 inhibitor, with an IC 50 value of 1.33 μM.

PMV6-PEG4-BI2536 is an RIPTAC-like bifunctional molecule that promotes the formation of the p53 Y 220C -PLK1 ternary complex ( EC 50 = 1.4 μM).

Tubulin polymerization-IN-84 inhibits tubulin polymerization by targeting the colchicine-binding pocket, with an IC 50 = 10.9 μM.

ATC12 is a Aurora-A kinase inhibitor.

LY3295668 (AK-01) erbumine is a highly specific and orally active inhibitor of Aurora-A kinase with a K i values for AurA and AurB of 0.8 nM and 1038 nM respectively.

HDAC-IN-98 is a HDAC1, HDAC2, HDAC3 inhibitor (one of the most selective class I HDAC inhibitors) with human IC 50 values of 41.2 nM, 52.5 nM, and 74.3 nM respectively.