Ferroptosis
Ferroptosis is a unique iron-dependent form of nonapoptotic cell death. It is triggered by oncogenic RAS-selective lethal small molecule erastin. Acitvation of ferroptosis lead to nonapoptotic destruction of cancer cells.
Products Related to Ferroptosis(211)
- GC73225ROS-generating agent 1CAS: 2369030-41-9Purity: >99.00%
يقوم ROS-generating agent 1 (المركب 2c) بتعديل تساهمي لبقايا Sec-498 من TrxR لتوليد ROS.
- GC73368Tubulin inhibitor 30CAS: 2873383-67-4Purity: >99.00%
Tubulin inhibitor 30 (المركب 15) هو مثبط تجميع تيوبيولين مع IC50 من 0.52 ميكرومتر.
- GC73838TfR-1-IN-1CAS: 1643444-62-5Purity: >96.00%
TfR-1-IN-1 (مركب C4) هو مثبط لمستقبل الترانسفيرين 1 (TfR-1) مع نشاط مضاد للسرطان.
- GC74018Ferroptosis-IN-6CAS: 1517780-59-4Purity: >98.00%
Ferroptosis-IN-6 (المركب 13) هو مثبط قوي من Ferroptosis مع EC50 من 25.5 نانومتر.
- GC74728Butylated hydroxytoluene-d3CAS: 86819-59-2Purity: >98.00%
Butylated hydroxytoluene-d3 هو الديوتيريوم المسمى دروكسيتولوين بوتيلاتيد.
- GC789442',4-DihydroxychalconeCAS: 13323-66-5Purity: >98.00%
2',4-Dihydroxychalcone is an orally active natural chalcone flavonoid.
- GC78976NFE2L1 activator-1CAS: 3070514-51-8Purity: >98.50%
NFE2L1 activator-1 (Compound 5b) is a potent nuclear factor erythroid 2-related factor 1 ( NFE2L1 ) activator ( EC 50 = 2.4 µM).
- GC78979Ferfluor-1CAS: 3030473-59-4Purity: >99.00%
Ferfluor-1 is a Ferroptosis inhibitor ( EC 50 of 57 nM in HT108 cells; EC 50 of 75 nM in OS-RC-2 cells; EC 50 of 2.3 nM in SH-SY5Y neuroblastoma cells), and ratiometric photoluminescent probe with blood-brain barrier permeability.
- GC79872RhoNox-4CAS: 2711762-70-6Purity: >98.50%
RhoNox-4 is a ferroptosis inhibitor and a fluorescence activation indicator specific to Fe 2+. RhoNox-4 selectively reacts with labile Fe 2+ and oxidizes it to Fe 3+, depleting labile Fe 2+ involved in lipid peroxidation and inhibiting ferroptosis induced by ferroptosis inducers.
- GC79873LPd peroxida probe-2CAS: 3092823-52-1Purity: >99.00%
LPd peroxida probe-2 (Compound I-1) is a lipid peroxidation fluorescent indicator (Ex = 488 nm, Em = 535 nm).
- GC81538RSL3-NH2 hydrochlorideCAS: 3051815-40-5Purity: >98.00%
RSL3-NH2 hydrochloride is a GPX4 inhibitor and ferroptosis inducer.
- GC81543GPX4-IN-19CAS: 3102894-57-2Purity: >99.00%
GPX4-IN-19 is an effective GPX4 inhibitor ( IC 50 = 0.311 μM), covalently binds to the Sec 46 site of GPX4.
- GC81545Ferroptosis inducer-12Purity: >96.00%
Ferroptosis inducer-12 is a potent and selective ferroptosis inducer.
- GC81575ZIP14-IN-1CAS: 1048-17-5Purity: >99.50%
ZIP 14-IN-1 (PPTD) is a selective and orally active ZIP14 inhibitor.
- GC81611Nrf2-IN-4 hydrobromidePurity: >99.00%
Nrf2-IN-4 (Compound PhcY) hydrobromide is a Nrf2 inhibitor.
- GC816342-Acetamidophenol-d 3CAS: 122258-87-1Purity: >99.00%
2-Acetamidophenol -d 3 (Orthocetamol-d 3 ) is the deuterium labeled 2-Acetamidophenol.
- GC81638PROTAC GPX4 degrader-5CAS: 3119292-91-7Purity: >95.00%
PROTAC GPX4 degrader-5 (compound N15) is an efficient and highly selective PROTAC GPX4 degrader ( DC 50 = 28 nM).
- GC81695DIM-3,5-Cl2CAS: 2595179-74-9Purity: >99.00%
DIM-3,5-Cl2 is an inverse NR4A1/NR4A2 agonist with K D values of 7.7 μM and 12.0 μM for NR4A1 and NR4A2, respectively.
- GC81758HDAC11-IN-5Purity: >98.00%
HDAC11-IN-5 is a selective, potent and orally active HDAC11 inhibitor with an IC 50 of 0.021 μM.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC73225 | ROS-generating agent 1 | 2369030-41-9 | >99.00% | |
يقوم ROS-generating agent 1 (المركب 2c) بتعديل تساهمي لبقايا Sec-498 من TrxR لتوليد ROS. | ||||
| GC73368 | Tubulin inhibitor 30 | 2873383-67-4 | >99.00% | |
Tubulin inhibitor 30 (المركب 15) هو مثبط تجميع تيوبيولين مع IC50 من 0.52 ميكرومتر. | ||||
| GC73420 | W1131 TFA | - | >99.00% | |
W1131 TFA هو مثبط قوي STAT3 الذي يحفز فيروبوتسيس. | ||||
| GC73589 | GPX4-IN-6 | 2922824-07-3 | >99.00% | |
GPX4-IN-6 (المركب C25) هو مثبط تساهمي GPX4 بقيمة IC50 0.13 ميكرومتر. | ||||
| GC73838 | TfR-1-IN-1 | 1643444-62-5 | >96.00% | |
TfR-1-IN-1 (مركب C4) هو مثبط لمستقبل الترانسفيرين 1 (TfR-1) مع نشاط مضاد للسرطان. | ||||
| GC74018 | Ferroptosis-IN-6 | 1517780-59-4 | >98.00% | |
Ferroptosis-IN-6 (المركب 13) هو مثبط قوي من Ferroptosis مع EC50 من 25.5 نانومتر. | ||||
| GC74728 | Butylated hydroxytoluene-d3 | 86819-59-2 | >98.00% | |
Butylated hydroxytoluene-d3 هو الديوتيريوم المسمى دروكسيتولوين بوتيلاتيد. | ||||
| GC78944 | 2',4-Dihydroxychalcone | 13323-66-5 | >98.00% | |
2',4-Dihydroxychalcone is an orally active natural chalcone flavonoid. | ||||
| GC78976 | NFE2L1 activator-1 | 3070514-51-8 | >98.50% | |
NFE2L1 activator-1 (Compound 5b) is a potent nuclear factor erythroid 2-related factor 1 ( NFE2L1 ) activator ( EC 50 = 2.4 µM). | ||||
| GC78979 | Ferfluor-1 | 3030473-59-4 | >99.00% | |
Ferfluor-1 is a Ferroptosis inhibitor ( EC 50 of 57 nM in HT108 cells; EC 50 of 75 nM in OS-RC-2 cells; EC 50 of 2.3 nM in SH-SY5Y neuroblastoma cells), and ratiometric photoluminescent probe with blood-brain barrier permeability. | ||||
| GC79872 | RhoNox-4 | 2711762-70-6 | >98.50% | |
RhoNox-4 is a ferroptosis inhibitor and a fluorescence activation indicator specific to Fe 2+. RhoNox-4 selectively reacts with labile Fe 2+ and oxidizes it to Fe 3+, depleting labile Fe 2+ involved in lipid peroxidation and inhibiting ferroptosis induced by ferroptosis inducers. | ||||
| GC79873 | LPd peroxida probe-2 | 3092823-52-1 | >99.00% | |
LPd peroxida probe-2 (Compound I-1) is a lipid peroxidation fluorescent indicator (Ex = 488 nm, Em = 535 nm). | ||||
| GC81430 | 3-Hydroxyindole | 480-93-3 | >87.50% | |
3-Hydroxyindole is a hydroxyindole compound. | ||||
| GC81439 | SZ0232 | 924851-91-2 | >99.00% | |
SZ0232 is a selective mPGES-2 inhibitor. | ||||
| GC81538 | RSL3-NH2 hydrochloride | 3051815-40-5 | >98.00% | |
RSL3-NH2 hydrochloride is a GPX4 inhibitor and ferroptosis inducer. | ||||
| GC81543 | GPX4-IN-19 | 3102894-57-2 | >99.00% | |
GPX4-IN-19 is an effective GPX4 inhibitor ( IC 50 = 0.311 μM), covalently binds to the Sec 46 site of GPX4. | ||||
| GC81545 | Ferroptosis inducer-12 | - | >96.00% | |
Ferroptosis inducer-12 is a potent and selective ferroptosis inducer. | ||||
| GC81546 | iMQT_020 | 2463893-46-9 | >99.00% | |
iMQT_020 is a selective allosteric SLC1A5_var inhibitor. | ||||
| GC81575 | ZIP14-IN-1 | 1048-17-5 | >99.50% | |
ZIP 14-IN-1 (PPTD) is a selective and orally active ZIP14 inhibitor. | ||||
| GC81611 | Nrf2-IN-4 hydrobromide | - | >99.00% | |
Nrf2-IN-4 (Compound PhcY) hydrobromide is a Nrf2 inhibitor. | ||||
| GC81634 | 2-Acetamidophenol-d 3 | 122258-87-1 | >99.00% | |
2-Acetamidophenol -d 3 (Orthocetamol-d 3 ) is the deuterium labeled 2-Acetamidophenol. | ||||
| GC81638 | PROTAC GPX4 degrader-5 | 3119292-91-7 | >95.00% | |
PROTAC GPX4 degrader-5 (compound N15) is an efficient and highly selective PROTAC GPX4 degrader ( DC 50 = 28 nM). | ||||
| GC81695 | DIM-3,5-Cl2 | 2595179-74-9 | >99.00% | |
DIM-3,5-Cl2 is an inverse NR4A1/NR4A2 agonist with K D values of 7.7 μM and 12.0 μM for NR4A1 and NR4A2, respectively. | ||||
| GC81758 | HDAC11-IN-5 | - | >98.00% | |
HDAC11-IN-5 is a selective, potent and orally active HDAC11 inhibitor with an IC 50 of 0.021 μM. | ||||