Ro 25-1553 acetate is a selective VIP 2 receptor ( VPAC 2 receptor ) agonist. Ro 25-1553 acetate exhibits bronchodilatory effects on tracheal smooth muscle contractions induced by nerve stimulation or Carbachol. Ro 25-1553 acetate produces a superimposed effect when combined with Formoterol and Salmeterol. Ro 25-1553 acetate can be used for the study of bronchoconstriction [1].
In Vitro, Ro 25-1553 (1×10-11 to 1×10-6 mol l-1) acetate potently induces complete, concentration-dependent relaxation of isolated guinea pig tracheal smooth muscle strips pre-contracted with Carbachol; pD2 value is 8.57 when the pre-contraction concentration of Carbachol is 0.1 μmol l-1, and 7.69 when the pre-contraction concentration of Carbachol is 1.0 μmol l-1[1]. Ro 25-1553 (1×10-11 to 1×10-6 mol l-1) acetate exerts an additive effect with Formoterol to relax isolated guinea pig tracheal smooth muscle strips pre-contracted by 0.1 μmol l-1 Carbachol[1]. Ro 25-1553 (1×10-10 to 1×10-4 mol l-1) acetate potently and completely inhibits vagus nerve-induced contractions in isolated guinea pig tracheal preparations; the pD2 value is 8.31 when administered extraluminally and 6.32 when administered intraluminally[1].
References:
[1]. Källström BL, et al. Bronchodilating properties of the VIP receptor agonist Ro 25-1553 compared to those of formoterol on the guinea-pig isolated trachea. Eur J Pharmacol. 2001;430(2-3):335-340.
In Vitro, Ro 25-1553 (1×10-11 to 1×10-6 mol l-1) acetate potently induces complete, concentration-dependent relaxation of isolated guinea pig tracheal smooth muscle strips pre-contracted with Carbachol; pD2 value is 8.57 when the pre-contraction concentration of Carbachol is 0.1 μmol l-1, and 7.69 when the pre-contraction concentration of Carbachol is 1.0 μmol l-1[1]. Ro 25-1553 (1×10-11 to 1×10-6 mol l-1) acetate exerts an additive effect with Formoterol to relax isolated guinea pig tracheal smooth muscle strips pre-contracted by 0.1 μmol l-1 Carbachol[1]. Ro 25-1553 (1×10-10 to 1×10-4 mol l-1) acetate potently and completely inhibits vagus nerve-induced contractions in isolated guinea pig tracheal preparations; the pD2 value is 8.31 when administered extraluminally and 6.32 when administered intraluminally[1].
References:
[1]. Källström BL, et al. Bronchodilating properties of the VIP receptor agonist Ro 25-1553 compared to those of formoterol on the guinea-pig isolated trachea. Eur J Pharmacol. 2001;430(2-3):335-340.