Sabeluzole

Sabeluzole (R 58735), a benzothiazol derivative, has antiischemic, antiepileptic, and cognitive-enhancing properties. Sabeluzole protects rat hippocampal neurons against NMDA- and glutamate-induced neurotoxicity via preventing tau expression. Sabeluzole enhances memory in rats, and prevents the amnesic effect of Chlordiazepoxide. Sabeluzole can be used fro research of Alzheimer's disease.

Sabeluzole (50 nM, 100 nM; 20 min before cell injury) exhibits protection in glutamate (50 μM)-mediated excitotoxicity in primary culture of cerebellar granule cell^[1].
Sabeluzole (50 nM; 7 d) inhibits tau protein level increase induced by glutamate^[1].
Sabeluzole (50 nM; 4 d) shows neuroprotective effects in human neuroblastoma cell line SH-SY5Y^[1].

Sabeluzole (5 mg/kg, 25 mg/kg; sc; twice dose with 72 h interval) shows positive and memory enhancing properties in habituation amnesia male rats induced with 20 mg/kg Chlordiazepoxide^[2].

References:
[1]. Uberti D, et al. Priming of cultured neurons with sabeluzole results in long-lasting inhibition of neurotoxin-induced tau expression and cell death. Synapse. 1997 Jun;26(2):95-103.
[2]. Hlinák Z,et al. Sabeluzole improves social recognition and antagonizes chlordiazepoxide's effect on habituation in the rat. Psychopharmacology (Berl). 1991;104(4):505-9.